Iron absorption in carriers of the C282Y hemochromatosis mutation
نویسندگان
چکیده
منابع مشابه
Iron absorption in carriers of the C282Y hemochromatosis mutation.
Hereditary hemochromatosis is a disorder of iron homeostasis in which the body iron content may be greatly increased. Most patients with hereditary hemochromatosis are homozygous for the C282Y mutation of the HFE gene. Because the iron content of the body is regulated by modulation of iron absorption, the increased body iron of those who are homozygous for the C282Y mutation must be due to enha...
متن کاملIron absorption by heterozygous carriers of the HFE C282Y mutation associated with hemochromatosis.
BACKGROUND Research conducted before genotyping was possible suggested that subjects heterozygous for the genetic mutation associated with hemochromatosis absorbed nonheme iron more efficiently than did control subjects when tested with a fortified meal. Heme-iron absorption in these subjects has not been reported. OBJECTIVE We compared the absorption of heme and nonheme iron from minimally o...
متن کاملRedox active plasma iron in C282Y/C282Y hemochromatosis.
Labile plasma iron (LPI) represents the redox active component of non-transferrin-bound iron (NTBI). Its presence in thalassemic patients has been recently reported. The aim of the present study was to quantify LPI in HFE genetic hemochromatosis (GH) and to characterize the mechanisms accounting for its appearance. We studied 159 subjects subdivided into the following groups: (1) 23 with iron o...
متن کاملPreeclampsia and the C282Y mutation in the hemochromatosis (HFE) gene.
To the Editor: The hemochromatosis (HFE) gene encodes the HFE protein, a transmembrane glycoprotein that is implicated in the modulation of iron uptake from the diet (1 ). The C282Y mutation in this gene is known to be associated with moderately increased serum iron indices. Recently, several studies have described an association between increased maternal iron status and an unfavorable pregnan...
متن کاملIron transport in a lymphoid cell line with the hemochromatosis C282Y mutation.
The gene for hemochromatosis (HFE) is expressed in a variety of cells, including those not thought to be affected by this disease. The impact of HFE on iron transport was examined in B-lymphoid cell lines developed from a patient with hemochromatosis with the HFE C282Y mutation (C282Y cells) and an individual with the wild-type HFE gene (WT cells). Whereas both cell lines expressed HFE protein,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2004
ISSN: 0002-9165,1938-3207
DOI: 10.1093/ajcn/80.4.799